Relationship between individual ventilatory response and acute renal water excretion at high altitude.
We tested the hypothesis that the individual ventilatory adaptation to high altitude (HA, 5050 m) may influence renal water excretion in response to water loading. In 8 healthy humans (33+/-4 S.D. years) we studied, at sea level (SL) and at HA, resting ventilation (VE), arterial oxygen saturation (SpO2), urinary output after water loading (WL, 20 mL/kg), and total body water (TBW). Ventilatory response to HA was defined as the difference in resting VE over SpO2 (DeltaVE/DeltaSpO2) from SL to HA. At HA, a significant increase in urinary volume after the first hour from WL (%WLt0-60) was observed. Significant correlations were found between DeltaVE/DeltaSpO2 versus %WLt0-60 at HA and versus changes in TBW, from SL to HA. In conclusion, in healthy subjects the ventilatory response to HA influences water balance and correlates with kidney response to WL. A higher ventilatory response at HA, allowing a more efficient water renal handling, is likely to be a protective mechanisms from altitude illness.
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Citation proposal
Gabriele Valli (Department of Clinical Medicine, University La Sapienza) - Daniela Bonardi (Institute of Diseases of the Respiratory System) - F.Campigotto () - Valter Fasano (Institute of Diseases of the Respiratory System) - Alessandra Gennari (National Institute for Cancer Research, Genova) - Luca Pomidori (Department of Biomedical sciences and advanced therapies, University of Ferrara) - Annalisa Cogo (Biomedical Research Centre applied to sport, University of Ferrara) - Paolo Palange (Clinical Medicine Department, Sapienza University of Rome) (2008) . Relationship between individual ventilatory response and acute renal water excretion at high altitude.. Elsevier Science Publishing Company https://geoportal.mountaingenius.org/geonetwork/srv/api/records/462f5015-b5e8-4e3a-af8b-97ce88b923e6 |
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- Hypoxia , arterial oxygen saturation , Hypobaria , Water excretion , Ventilation , Kidney
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- high altitude
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“Relationship between individual ventilatory response and acute renal water excretion at high altitude.”
Valli G, Bonardi D, Campigotto F, Fasano V, Gennari A, Pomidori L, Cogo A, Palange P.
Respir Physiol Neurobiol. 2008 Jul 31;162(2):103-8. Epub 2008 Apr 30.
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- Institute of Diseases of the Respiratory System
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- valter.fasano@unimi.it
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- National Institute for Cancer Research, Genova
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- Department of Biomedical sciences and advanced therapies, University of Ferrara
- luca.pomidori@unife.it
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- Biomedical Research Centre applied to sport, University of Ferrara
- annalisa.cogo@unife.it
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- Clinical Medicine Department, Sapienza University of Rome
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- nlinfo@sciencedirect.com
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- valter.fasano@unimi.it
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- National Institute for Cancer Research, Genova
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- Department of Biomedical sciences and advanced therapies, University of Ferrara
- luca.pomidori@unife.it
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- Biomedical Research Centre applied to sport, University of Ferrara
- annalisa.cogo@unife.it
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- nlinfo@sciencedirect.com
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