462f5015-b5e8-4e3a-af8b-97ce88b923e6 eng Ev-K2-CNR +39 035 3230511 +39 035 3230551 Via San Bernardino 145 Bergamo BG 24126 Italy metadata@evk2cnr.org http://www.evk2cnr.org/ 2025-02-21T19:04:26 ISO 19115:2003/19139 1.0 Relationship between individual ventilatory response and acute renal water excretion at high altitude. 2008-04-30T00:00:00 Respiratory physiology & neurobiology, 162(2):103-8. Respiratory physiology & neurobiology 1569-9048 We tested the hypothesis that the individual ventilatory adaptation to high altitude (HA, 5050 m) may influence renal water excretion in response to water loading. In 8 healthy humans (33+/-4 S.D. years) we studied, at sea level (SL) and at HA, resting ventilation (VE), arterial oxygen saturation (SpO2), urinary output after water loading (WL, 20 mL/kg), and total body water (TBW). Ventilatory response to HA was defined as the difference in resting VE over SpO2 (DeltaVE/DeltaSpO2) from SL to HA. At HA, a significant increase in urinary volume after the first hour from WL (%WLt0-60) was observed. Significant correlations were found between DeltaVE/DeltaSpO2 versus %WLt0-60 at HA and versus changes in TBW, from SL to HA. In conclusion, in healthy subjects the ventilatory response to HA influences water balance and correlates with kidney response to WL. A higher ventilatory response at HA, allowing a more efficient water renal handling, is likely to be a protective mechanisms from altitude illness. Gabriele Valli Department of Clinical Medicine, University La Sapienza V.le Universita 37 Roma ROMA 00185 Italy valli.gabriele@fastwebnet.it http://w3.uniroma1.it/scialim/index.php?pag=266 Daniela Bonardi Institute of Diseases of the Respiratory System +39 0255033716 +39 0250320628 Via F.Sforza,35 Milano MI 20122 Italy www.unimi.it F.Campigotto Valter Fasano Institute of Diseases of the Respiratory System Via F.Sforza, 35 Milano MI 20122 Italy valter.fasano@unimi.it www.unimi.it Alessandra Gennari National Institute for Cancer Research, Genova +39 010 5737369 L.go Rosanna Benzi, 10 Genova GE 16132 Italy alessandra.gennari@istge.it http://www.istge.it Luca Pomidori Department of Biomedical sciences and advanced therapies, University of Ferrara +39 3287858417 Corso Giovecca, 203 Ferrara FE 44100 Italy luca.pomidori@unife.it www.unife.it Annalisa Cogo Biomedical Research Centre applied to sport, University of Ferrara Associate Professor in Respiratory Diseases, Director of the Biomedical Sport Study Center 0039 0532210420 0039 0532455977 0039 0532210297 Via Gramicia,35 Ferrara FE 44123 Italy annalisa.cogo@unife.it http://www.unife.it/centri/centro/studi-biomedici Paolo Palange Clinical Medicine Department, Sapienza University of Rome +39 0649972082 +39 0649972057 +39 064940421 V.le University,37 Roma ROMA 00185 Italy paolo.palange@uniroma1.it www.unimi.it Elsevier Science Publishing Company PO Box 211 Amsterdam 100 AE Netherlands nlinfo@sciencedirect.com http://www.elsevier.com https://geoportal.mountaingenius.org/geonetwork/srv/api/records/462f5015-b5e8-4e3a-af8b-97ce88b923e6/attachments/elsevier-non-solus.png elsevier-non-solus.png Hypoxia arterial oxygen saturation Hypobaria Water excretion Ventilation Kidney high altitude SHARE eng health -180 180 -90 90 http://www.sciencedirect.com/science/article/pii/S1569904808001109 WWW:LINK-1.0-http--link Article:"Relationship between individual ventilatory response and acute renal water excretion at high altitude." “Relationship between individual ventilatory response and acute renal water excretion at high altitude.” Valli G, Bonardi D, Campigotto F, Fasano V, Gennari A, Pomidori L, Cogo A, Palange P. Respir Physiol Neurobiol. 2008 Jul 31;162(2):103-8. Epub 2008 Apr 30.