f8ce9468-fa65-4818-8afb-06a5d2184c61 eng 1db1421f-9289-4687-9514-49fa29f7c2fb Ev-K2-CNR +39 035 3230511 +39 035 3230551 Via San Bernardino 145 Bergamo BG 24126 Italy metadata@evk2cnr.org http://www.evk2cnr.org/ 2011-10-25T21:11:51 ISO 19115:2003/19139 1.0 The Lung at high altitude: between physiology and pathology in Problems of high altitude medicine and biology 2007-09-24T00:00:00 Problems of High Altitude Medicine and Biology 119-132 NATO Science for Peace and Security Series A: Chemistry and Biology 1402062982 The lungs play a pivotal role in adaptation to high altitude. The increase in ventilation and the rise in pulmonary artery pressure are the first features of lung response to hypoxic exposure. At high altitude the lungs can also be affected by high-altitude pulmonary oedema, a severe form of acute mountain sickness. In healthy subjects the ascent to high altitude is also associated with alterations in lung function, which have been in part interpreted as an effect of extra vascular lung fluid accumulation. The patterns of respiratory function changes at high altitude are discussed, taking into account the body fluid movement and the increase in endothelial permeability induced by hypoxic exposure. As the problem of “respiratory” patients at high altitude is very important, a short summary of the guidelines for altitude exposure of asthmatic and COPD patients is reported at the end of the chapter. This book is directly derived from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake of Issyk-Kul, in Kyrghyzstan, in June 5-6, 2006. The meeting was remarkable by several aspects. The participants enjoyed the beauty of the blue waters of this 1610 m high sacred lake, with stunning view on the Tien Shan mountain range at a distance, and, most of all, the wonderful Kyrghyz hospitality and friendship. It was a surprise for several European and North and South-American scientists to discover the still on-going momentum high level altitude physiology research, which was extremely active but insufficiently acknowledged in this remote Central Asian country at the time of the USSR. Accordingly, the setting was perfect for numerous positive scientific interactions, exchanges of ideas, and structuring of new international collaborations. Overall, the meeting was an ideal mix of cell biology, integrative physiology and medical applications. Thanks to the efforts of both English and Russian speaking scientist participants, this comes out very well in this book. Hypoxia is and remains a major public health issue in many populated mountainous areas all over the world. We are sure that this book will be become a long-lasting essential reference. Almaz Aldashev Robert Naeije SPRINGER +49 62213454303 springerlink@springer.com http://www.springerlink.com/ Annalisa Cogo Biomedical Research Centre applied to sport, University of Ferrara +39 0532 210420 +39 0532 455888 +39 0532 210297 Via Gramicia, 35 Ferrara FE 44123 Italy annalisa.cogo@unife.it http://www.unife.it/centri/centro/studi-biomedici Federica Campigotto Biomedical Research Centre applied to sport, University of Ferrara Via Gramicia, 35 Ferrara FE 44123 Italy http://www.unife.it/centri/centro/studi-biomedici Valter Fasano Institute of Diseases of the Respiratory System Via F.Sforza, 35 Milano MI 20122 Italy valter.fasano@unimi.it www.unimi.it Giovanni Grazzi Biomedical Research Centre applied to sport, University of Ferrara +39 0532 455974 Via Gramicia, 35 Ferrara FE 44100 Italy giovanni.grazzi@unife.it http://www.unife.it/centri/centro/studi-biomedici https://geoportal.mountaingenius.org/geonetwork/srv/eng/resources.get?uuid=f8ce9468-fa65-4818-8afb-06a5d2184c61&fname=mountain_witness__s.png thumbnail png SHARE Biology Security Science Chemistry NATO High altitude pulmonary artery pressure physiology eng elevation health -180 180 -90 90 http://books.google.it/books?id=Afo8MRxCXgYC&printsec=frontcover&source=gbs_atb#v=onepage&q&f=false WWW:LINK-1.0-http--related Preview of the book. http://www.springer.com/new+%26+forthcoming+titles+(default)/book/978-1-4020-6298-8 WWW:LINK-1.0-http--related About this book. http://books.google.it/books?id=Afo8MRxCXgYC&pg=PA119&lpg=PA119&dq=The+Lung+at+high+altitude:+between+physiology+and+pathology+in+Problems+of+high+altitude+medicine+and+biology&source=bl&ots=SYaNApK0Aa&sig=0m68J-qKAz_sLNIU5B4Oi-YBjM8&hl=it&ei=UAmnTvWLLc3AtAbWyJjRDQ&sa=X&oi=book_result&ct=result&resnum=1&ved=0CB8Q6AEwAA#v=onepage&q=The%20Lung%20at%20high%20altitude%3A%20between%20physiology%20and%20pathology%20in%20Problems%20of%20high%20altitude%20medicine%20and%20biology&f=false WWW:LINK-1.0-http--related Preview of the Chapter 8:"The Lung at high altitude: between physiology and pathology in Problems of high altitude medicine and biology." Chapter 8:" Lung at high altitude: between physiology and pathology"; A. Cogo et al. Page 119-132 "Problems of High Altitude Medicine and Biology". Collective title NATO Security Through Science Series A: Chemistry and Biology ISBN 1402062982