d182c72a-c718-4336-b9e8-c2a371ef31dc eng Ev-K2-CNR +39 035 3230511 +39 035 3230551 Via San Bernardino 145 Bergamo BG 24126 Italy metadata@evk2cnr.org http://www.evk2cnr.org/ 2011-11-01T16:00:33 ISO 19115:2003/19139 1.0 Airway Responses to Methacholine and exercise at High Altitude in Healthy Lowlanders. 2009-09-25T00:00:00 Journal of Applied Physiology 108 256-265 Journal of Applied Physiology, 108: 256-265. Journal of Applied Physiology 8750-7587 Peribronchial edema has been proposed as a mechanism enhancing airway responses to constrictor stimuli. Acute exposure to altitude in nonacclimatized lowlanders leads to subclinical interstitial pulmonary edema that lasts for several days after ascent, as suggested by changes in lung mechanics. We, therefore, investigated whether changes in lung mechanics consistent with fluid accumulation at high altitude within the lungs are associated with changes in airway responses to methacholine or exercise. Fourteen healthy subjects were studied at 4,559 and at 120 m above sea level. At high altitude, both static and dynamic lung compliances and respiratory reactance at 5 Hz significantly decreased, suggestive of interstitial pulmonary edema. Resting minute ventilation significantly increased by ?30%. Compared with sea level, inhalation of methacholine at high altitude caused a similar reduction of partial forced expiratory flow but less reduction of maximal forced expiratory flow, less increments of pulmonary resistance and respiratory resistance at 5 Hz, and similar effects of deep breath on pulmonary and respiratory resistance. During maximal incremental exercise at high altitude, partial forced expiratory flow gradually increased with the increase in minute ventilation similarly to sea level but both achieved higher values at peak exercise. In conclusion, airway responsiveness to methacholine at high altitude is well preserved despite the occurrence of interstitial pulmonary edema. We suggest that this may be the result of the increase in resting minute ventilation opposing the effects and/or the development of airway smooth muscle force, reduced gas density, and well preserved airway-to-parenchyma interdependence. Iliana Torres Journal of Applied Physiology 3016347252 3016347243 9650 Rockville Pike Bethesda Maryland 20814 United States of America itorres@the-aps.org http://jap.physiology.org/ Riccardo Pellegrino Allergy and Respiratory Physiopathology, Hospital S. Croce and Carle, 335701162 +39 0171616728 +39 0171616798 Via M. Coppino, 26 CUNEO CN 12100 Italy pellegrino.r@ospedale.cuneo.it http://www.ospedale.cuneo.it/ Pasquale Pompilio TBMLab Laboratory of Biomedical Technologies, Polytechnic of Milan" (Technical University) +39 0223999024 +39 0223999000 V.Colombo, 40 Milano MI 20133 Italy pasquale.pompilio@polimi.it http://www.tbmlab.polimi.it Marco Quaranta TBMLab Laboratory of Biomedical Technologies, Polytechnic of Milan" (Technical University) V.Colombo, 40 Milano Mi 20133 Italy marco.quaranta@polimi.it http://www.tbmlab.polimi.it Andrea Aliverti TBMLab Laboratory of Biomedical Technologies, Polytechnic of Milan +39 0223999006 +39 0223999000 V.Colombo, 40 Milano MI 20133 Italy andrea.aliverti@polimi.it http://www.tbmlab.polimi.it Bengt Kayser Institute of movement sciences and sports medicine, University of Geneva +41 223790027 +41 223790028 +41 223790035 10 rue du conseil-Général Genève Genève cH-1205 Switzerland kayser@cmu.unige.ch Bengt.Kayser@unige.ch http://www.unige.ch/ Giuseppe Miserocchi Department of Experimental medicine, University of Milano-Bicocca +39 02 6448 8309 +39 02 6448 Via Cadore 48 Monza MB 20052 Italy giuseppe.miserocchi@unimib.it http://www.dimesab.medicina.unimib.it Valter Fasano Department of Cardio Thoracic and Vascular Desease, University of Milan via F. Sforza, 35 Milano MI 20122 Italy valter.fasano@unimi.it http://www.unimi.it/ Annalisa Cogo Biomedical Research Centre applied to sport,University of Ferrara 0039 0532210420 0039 0532455977 0039 0532210297 Via Gramicia, 35 Ferrara FE 44123 Italy annalisa.cogo@unife.it http://www.unife.it/centri/centro/studi-biomedici Manlio Milanese Pneumology, Hospital S. Corona, Pietra Ligure +39 0196232789 Via XXV Aprile, 38 Pietra Ligure SV 17027 Italy http://www.asl2.liguria.it Giuseppe Cornara Anaesthesia and Intensive Care, Hospital St. Croce and Carle +39 0171 642212 +39 0171 642664 Via M. Coppino, 26 Cuneo CN 12100 Italy cornara.g@ospedale.cuneo.it http://www.ospedale.cuneo.it/ Vito Brusasco Respiratory Pathophysiology, Department of Internal Medicine, University of Genova +39 0103537690 Viale Benedetto XV,10 Genova GE 16132 Italy Vito.Brusasco@unige.it http://www.unige.it Raffaele Dellacà Department of Bioengineering, Polytechnic of Milan +39 0223999005 +39 02 2399 9000 Via Golgi, 39 Milano MI 20133 Italy raffaele.dellaca@polimi.it http://www.tbmlab.polimi.it https://geoportal.mountaingenius.org/geonetwork/srv/eng/resources.get?uuid=d182c72a-c718-4336-b9e8-c2a371ef31dc&fname=mountain_witness__s.png thumbnail png SHARE Peribronchial edema respiratory resistance. sea level interstitial pulmonary edema fluid accumulation methacholine ventilation high altitude eng elevation health 6.62397 18.5144 36.6492 47.0946 http://jap.physiology.org/content/108/2/256.abstract WWW:LINK-1.0-http--link Abstract:"Airway responses to methacholine and exercise at high altitude in healthy lowlanders." https://geoportal.mountaingenius.org/webapp/srv/en/resources.get?id=28498&fname=J_Appl_Physiol-2010-Pellegrino-256-65.pdf.crdownload&access=private WWW:DOWNLOAD-1.0-http--download J_Appl_Physiol-2010-Pellegrino-256-65.pdf.crdownload Full text:"Airway responses to methacholine and exercise at high altitude in healthy lowlanders". “Airway Responses to Methacholine and exercise at High Altitude in Healthy Lowlanders. “ Journal of Applied Physiology, 108: 256-265. Pellegrino, R., P. Pompilio, M. Quaranta, A. Aliverti, B. Kayser, G. Miserocchi, V. Fasano, A. Cogo, M. Milanese, G. Cornara, V. Brusasco & R. Dellacà. 2010.