The aim of this contribution is to present the research activities which will be carried out in the frame of the Project “Institutional Consolidation for the Coordinated and Integrated Monitoring of Natural Resources towards Sustainable Development and Environmental Conservation in the Hindu Kush - Karakoram-Himalaya Mountain Complex”. The Project will be performed within the cooperation of four scientific partners: IUCN (International Union for the Conservation of Nature and Natural Resources), ICIMOD (International Centre for Integrated Mountain Development), Ev-K2-CNR and CESVI (NGO, Cooperazione e Sviluppo, onlus) with the involvement of international researchers. The local management will be provided in Nepal by the Sagarmatha National Park (SNP), in Pakistan by the Central Karakoram National Park (CNKP) and in Tibet Autonomous Region (China) by the Quomolongma Nature Preserve (QNP). This contribution will provide an overview about the research issues (on forests, biodiversity, glacier changes, livelihoods) mainly based on remote sensing technologies which could be successfully applied on CNKP. The need for integrating remote sensing data and field activities are presented as well. The applied image processing techniques (i.e. radiometric normalization, image geometric rectification and thematic classification) are introduced with an emphasis on the key role played by acquiring field data and evaluating the accuracy. The basis of this discussion is the creation of some base thematic maps realised mainly from remote sensing data.